In-depth analysis demonstrates that mitophagy is required for the beneficial effect of urolithin A (Ryu et al., 2016). In our trial, elevated urolithin A was correlated with walnut and Mankai consumption, as its precursor, ellagic acid , was found in both. The ellagitannins (ellagic acids) are metabolised to urolithins that are circulated in the plasma of consumers, thereby increasing the counts of bifidobacteria and lactobacilli. Ellagitannins (the main polyphenols in pomegranate juice) are hydrolyzed to ellagic acid, and then to urolithin A (UA) derivatives. Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. . Food Chem Toxicol 108: 289297, 2017. doi: 10.1016/j.fct.2017.07.050. Yuandi Lei, Tianyi Jiang, Liqin He, Yanping Liu, Zhanbing Sun, Weihua Deng, Lian Huang & Zhaohui Zhang. Anti-tumor immunity is limited by reduced T cell persistence and antigen presentation. . Various parts of the tree and fruit are used to make medicine. The Phoenix dactylifera extract led to attenuated cardiotoxicity and nephrotoxicity secondary to decreased oxidative stress and apoptotic pressure. According to a tissue distribution experiment in wild-type mice, the prostate gland rapidly takes up high concentrations of UA after oral or intraperitoneal administration (0.3 mg/mouse/dose). In our trial, elevated urolithin A was correlated with walnut and Mankai consumption, as its precursor, ellagic acid , was found in both. Ellagitannins (the main polyphenols in pomegranate juice) are hydrolyzed to ellagic acid, and then to urolithin A (UA) derivatives. Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. (1) Background: Ellagic acid (EA) acts as a product of gut microbiota transformation to prevent insulin resistance, which is limited by high-fat diet (HFD)-induced dysbiosis. Espn JC, Larrosa M, Garca-Conesa MT, Toms-Barbern F. Polyphenols can also detoxify gut metabolites and repress the growth of pathogenic bacteria, such as Clostridium perfringens, Clostridium difficile and Bacteroides spp. The aim of this study was to investigate the synergistic effects and mechanisms of supplementation with the probiotic Weizmannia coagulans (W. coagulans) on the prevention of insulin resistance by EA; Pomegranate is a tree. Urolithin B is one of the four metabolites of the Ellagic Acid/Ellagitannins family. The Phoenix dactylifera extract led to attenuated cardiotoxicity and nephrotoxicity secondary to decreased oxidative stress and apoptotic pressure. Polyphenols can also detoxify gut metabolites and repress the growth of pathogenic bacteria, such as Clostridium perfringens, Clostridium difficile and Bacteroides spp. Crossref | PubMed | ISI | Google Scholar; 22. Mc Cormack B, Maenhoudt N, Fincke V, Stejskalova A, Greve B, Kiesel L, et al. Urolithin A Attenuates Helicobacter pylori-Induced Damage In Vivo. Another dietary polyphenol such as ellagic acid and ellagitannins are transformed into urolithin A (an anti-inflammatory metabolite) by Gordonibacter spp. Hum Reprod. The ellagic acid metabolites urolithin A and B differentially affect growth, adhesion, motility, and invasion of endometriotic cells in vitro. Crossref | PubMed | ISI | Google Scholar; 22. Urolithin A Attenuates Helicobacter pylori-Induced Damage In Vivo. Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. Food Funct. It is a type of phenolic compound that is produced in the human gut after absorption of ellagitannin containing foods such as pomegranate, strawberries, . Crossref | PubMed | ISI | Google Scholar; 22. 2021;36:150119. (1) Background: Ellagic acid (EA) acts as a product of gut microbiota transformation to prevent insulin resistance, which is limited by high-fat diet (HFD)-induced dysbiosis. . Thus, urolithin A, the end-products of both ellagitannins and ellagic acid, extends lifespan and improves fitness during C. elegans aging and improves muscle function and exercise capacity in rodents. Among the various metabolites, Urolithin-A was found to be more dynamic by hindering the synthesis of Among the various metabolites, Urolithin-A was found to be more dynamic by hindering the synthesis of Studies suggest that the ellagic acid-rich fractions and metabolites of pomegranate urolithin-A provide a protective effect against colitis . (1) Background: Ellagic acid (EA) acts as a product of gut microbiota transformation to prevent insulin resistance, which is limited by high-fat diet (HFD)-induced dysbiosis. Food Funct. It belongs to the class of organic compounds known as benzo-coumarins or dibenzo--pyrones.Its precursors ellagic acids and ellagitannins are ubiquitous in nature, including edible plants, such as pomegranates, strawberries, raspberries, and walnuts. Urolithin A is a metabolite compound resulting from the transformation of ellagitannins by the gut bacteria. Revisin. Food Chem Toxicol 108: 289297, 2017. doi: 10.1016/j.fct.2017.07.050. Pomegranate is a tree. Espn JC, Larrosa M, Garca-Conesa MT, Toms-Barbern F. Hum Reprod. Nutr Hosp. Anti-tumor immunity is limited by reduced T cell persistence and antigen presentation. show that Urolithin A, a natural metabolite of pomegranate extract, enhances antigen presentation in cancer and promotes mitophagy in CD8+ T cells, resulting in generation regenerative stem cell-like memory (TSCM) cells with enhanced anti-tumor properties. Taninos hidrolizables; bioqumica, aspectos nutricionales y analticos y efectos en la salud. Taninos hidrolizables; bioqumica, aspectos nutricionales y analticos y efectos en la salud. Zhou B. Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose. Urolithin A is a metabolite compound resulting from the transformation of ellagitannins by the gut bacteria. According to a tissue distribution experiment in wild-type mice, the prostate gland rapidly takes up high concentrations of UA after oral or intraperitoneal administration (0.3 mg/mouse/dose). 318. Denk et al. Published online: 01 Jun 2022. It belongs to the class of organic compounds known as benzo-coumarins or dibenzo--pyrones.Its precursors ellagic acids and ellagitannins are ubiquitous in nature, including edible plants, such as pomegranates, strawberries, raspberries, and walnuts. Urolithin B is one of the four metabolites of the Ellagic Acid/Ellagitannins family. 2015;31(1):55-66 ISSN 0212-1611 CODEN NUHOEQ S.V.R. Urolithin B is one of the four metabolites of the Ellagic Acid/Ellagitannins family. 2021;36:150119. Pages: 1047-1054. . The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging. In-depth analysis demonstrates that mitophagy is required for the beneficial effect of urolithin A (Ryu et al., 2016). Among the various metabolites, Urolithin-A was found to be more dynamic by hindering the synthesis of It belongs to the class of organic compounds known as benzo-coumarins or dibenzo--pyrones.Its precursors ellagic acids and ellagitannins are ubiquitous in nature, including edible plants, such as pomegranates, strawberries, raspberries, and walnuts. Espn JC, Larrosa M, Garca-Conesa MT, Toms-Barbern F. Nutr Hosp. This mechanism led us to test Urolithin A, a common metabolite that promotes mitophagy and extends lifespan in C. elegans, as a possible therapeutic to delay reproductive decline. Article Google Scholar Food Funct. Espn JC, Larrosa M, Garca-Conesa MT, Toms-Barbern F. Denk et al. The ellagitannins (ellagic acids) are metabolised to urolithins that are circulated in the plasma of consumers, thereby increasing the counts of bifidobacteria and lactobacilli. Pomegranate is a tree. Crossref | PubMed | ISI | Google Scholar; 22. Zhou B. Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose. 9 , 41004106 (2018). show that Urolithin A, a natural metabolite of pomegranate extract, enhances antigen presentation in cancer and promotes mitophagy in CD8+ T cells, resulting in generation regenerative stem cell-like memory (TSCM) cells with enhanced anti-tumor properties. . It is a type of phenolic compound that is produced in the human gut after absorption of ellagitannin containing foods such as pomegranate, strawberries, Zhi-hao Yu, Mei Cao, Yuan-xiao Wang, Shi-ying Yan, Li-ting Qing, Cheng-meng Wu, Shu Li lncRNA MPFAST Promotes Proliferation and Fatty Acid Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway. Article PubMed Google Scholar Zhi-hao Yu, Mei Cao, Yuan-xiao Wang, Shi-ying Yan, Li-ting Qing, Cheng-meng Wu, Shu Li lncRNA MPFAST Promotes Proliferation and Fatty Acid Synthesis of Bovine Mammary Epithelial Cell by Sponging miR-103 Regulating PI3K-AKT Pathway. Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. The aim of this study was to investigate the synergistic effects and mechanisms of supplementation with the probiotic Weizmannia coagulans (W. coagulans) on the prevention of insulin resistance by EA; Revisin. 2021;36:150119. Jose Alberto Lpez-Daz 1, Emilio lvarez-Parrilla 1, Laura A. de la Rosa 1 y Arnulfo Ramos-Jimenez 1 Published online: 01 Jun 2022. It is a type of phenolic compound that is produced in the human gut after absorption of ellagitannin containing foods such as pomegranate, strawberries, Urolithin A Attenuates Helicobacter pylori-Induced Damage In Vivo. Ellagic acid attenuates beryllium sulphate-induced oxidative stress and histopathological alterations of spleen in rats. Anti-tumor immunity is limited by reduced T cell persistence and antigen presentation. Article PubMed Google Scholar Another dietary polyphenol such as ellagic acid and ellagitannins are transformed into urolithin A (an anti-inflammatory metabolite) by Gordonibacter spp. Ellagitannins (the main polyphenols in pomegranate juice) are hydrolyzed to ellagic acid, and then to urolithin A (UA) derivatives. Urolithin A, a metabolite compound resulting from the transformation of ellagitannins by gut bacteria, has been reported to have anti-oxidant, anti-inflammatory, and anti-apoptotic properties. Francisco Javier Olivas-Aguirre 1, Abraham Wall-Medrano 1, Gustavo A. Gonzlez-Aguilar 2, . Ellagic acid attenuates beryllium sulphate-induced oxidative stress and histopathological alterations of spleen in rats. Crossref | PubMed | ISI | Google Scholar; 22. Thus, urolithin A, the end-products of both ellagitannins and ellagic acid, extends lifespan and improves fitness during C. elegans aging and improves muscle function and exercise capacity in rodents. Nutr Hosp. In addition, plasma hippuric acid, a glycine conjugate of benzoic acid, both metabolites present in Mankai, was significantly associated with VAT reduction even after controlling for WC change. Espn JC, Larrosa M, Garca-Conesa MT, et al. 318. . According to a tissue distribution experiment in wild-type mice, the prostate gland rapidly takes up high concentrations of UA after oral or intraperitoneal administration (0.3 mg/mouse/dose). Various parts of the tree and fruit are used to make medicine. 318. . Revisin. Crossref | PubMed | ISI | Google Scholar; 22. Food Chem Toxicol 108: 289297, 2017. doi: 10.1016/j.fct.2017.07.050. This mechanism led us to test Urolithin A, a common metabolite that promotes mitophagy and extends lifespan in C. elegans, as a possible therapeutic to delay reproductive decline. [ 70 ]. Article Google Scholar Published online: 01 Jun 2022. Zhou B. Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose. Espn JC, Larrosa M, Garca-Conesa MT, et al. Pages: 1047-1054. Hum Reprod. The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging. The aim of this study was to investigate the synergistic effects and mechanisms of supplementation with the probiotic Weizmannia coagulans (W. coagulans) on the prevention of insulin resistance by EA; Espn JC, Larrosa M, Garca-Conesa MT, Toms-Barbern F. Yuandi Lei, Tianyi Jiang, Liqin He, Yanping Liu, Zhanbing Sun, Weihua Deng, Lian Huang & Zhaohui Zhang. The ellagic acid metabolites urolithin A and B differentially affect growth, adhesion, motility, and invasion of endometriotic cells in vitro. Studies suggest that the ellagic acid-rich fractions and metabolites of pomegranate urolithin-A provide a protective effect against colitis . Taninos hidrolizables; bioqumica, aspectos nutricionales y analticos y efectos en la salud. Article PubMed Google Scholar Urolithin A is a metabolite compound resulting from the transformation of ellagitannins by the gut bacteria. In-depth analysis demonstrates that mitophagy is required for the beneficial effect of urolithin A (Ryu et al., 2016).